The Final SceneEdit
Simone Mueller, who is Brady Armstrong's agent, tries to invent stage names for Nancy including Fancy Jackson and Samantha Quick. She may have met Samantha Quick before and subconsciously remembered the name when looking at Nancy, suggesting a resemblence. 
The Phantom of VeniceEdit
When Nancy follows a messenger pigeon to the exclusive game club Casa dei Giochi at Campo Santa Margherita in Venice in 2008, she looks through the dumpster for clues as to how to get in and finds a letter from the Doppeler Institute for Independent Industrial Arts, recommending their "star pupil" Samantha Quick for a project. The letter says that she will arrive some time after Carnivale and that she will be wearing black sunglasses, a red dress, white gloves and has blonde hair. After talking with her contact, Sophia Leporace, Nancy decides to pose as Samantha Quick in order to gain the crime ring's trust and purchases the clothes she needs, as well as a wig. She meets Enrico Tazza, who gives her the mission of stealing the Sadal Melik sapphire from Palazzo Zattere. After she does this, Tazza wires Samantha's payment to her Swiss bank account. All of this information means that Samantha is a thief and has blonde hair.
When Nancy asks Joe about the Doppeler Institute for Independent Industrial Arts, he says that someone mentioned it when he and Frank were on an ATAC mission. It's supposed to be a secretive school for spies, but it's so secret that no one is even sure if it really exists or not.
After Nancy has received her mission from Tazza, she returns to the Ca' Nascosta and recieves a threatening phone call from Samantha demanding that she never mess around in her businness ever again. See below:
Samantha: Don’t ever do that again.
Nancy: Do what again? Who is this?
Samantha: There’s only one of me. I like it that way. It’s going to stay that way.
Samantha: Do what you have to do for Tazza, but after that, the charade ends. Got that sister?
Nancy: But who are you? Where are you? How did you know it was me?
Samantha: Good questions. Too bad I’m not going to answer them. Just finish up and go back to River Heights, Nancy. ** Pause ** Oh, and… say hi to Ned for me.
** Call is disconnected **
Nancy (To herself): Who is she?
At the end of the game, Colin Baxter, whose real name is Justin Beaumont, is shown in Washington D.C. with a silhouette in his room, whom many have suspected to be Samantha Quick. Their connection would explain Samantha's knowledge of Ned. In Ransom of the Seven Ships, Coucou repeats "Samantha, this is Justin" and "Justin, meet Samantha", creating speculation that they met at Dread Isle.
Treasure on the TracksWhen the Hardy Boys are on the train from Paris in 2010, they get a phone call from a mysterious stranger, who later gives them "Samantha" as a name. She is actually Samantha Quick. At first, she does not show her face, but then later in the game dons various disguises shown here.
Samantha tells the boys that she is in Vienna, watching the man wearing the fez hat who seems to be involved in their case. When he plants a bomb on the tracks, Samantha disarms it.
Later, on the train from Vienna to Prague, the boys get another call from her saying that she is still tracking the man and watches an exchange between him and a flunky. When Frank and Joe get to Prague, they search for Samantha, and she calls them again to tell them of her progress.
In Warsaw, Frank and Joe give her the location they think the stolen painting has gone to, and Samantha heads there and talks to Alexey Konstantirev and Isabelle DuPont outside, determining that Alexey was blackmailed into painting over it. She sneaks inside, removes the new layer of the painting and sends a photo of it back to Frank and Joe, telling them that that will be their last conversation.
When asked why she is helping them, all Samantha will say is that her orders are to help the Hardy boys in their mission to find the Romanov fortune.
The Silent SpyEditNancy meets a young woman named Bridget Shaw in 2013 when she is investigating her mother's death in Scotland. Bridget takes a liking to Nancy instantly and wants to know more about her. However, Nancy can't reveal too much, since her mission is very dangerous. After snooping through Bridget's room, Nancy discovers she's been tracking her and confronts Bridget about it. Bridget says that she is sick of using that accent and walks away. Nancy completes a dead drop Bridget was going to do and gets some spy glasses addressed to Zoe Wolfe. Zoe later comes back outside the hotel and can talk to Nancy some more, threatening to get her sent back to America if she continues to try to get herself killed.
After Nancy bugs Zoe's room and hears her enter a combination to a secret compartment, she goes back and looks in it to find a number of IDs, one of which inidicates that she is Samantha Quick. When Nancy confronts her about this, she gets upset and says that she was meaning to talk to her about that, and that you don't steal someone's alias, saying it is so rude.
Towards the end of the game, Zoe takes the completed Colony formula from Nancy, but they are both gassed in the elevator and end up in the trash compactor. They escape, but the formula is gone. When Nancy recovers it, Revenant, the terrorist group Nancy and Zoe were fighting, had used the formula to create four bombs. Zoe upgrades the spy glasses so that she can communicate with Nancy through them and helps her disarm the bombs. She then helps Alec Fell look for his sister.
Zoe says that she works for an organization whose name only a few people know. When Nancy asks her about the bag and drag operation, she says that they were just people she slipped some cash and that she really does work alone.
Zoe is voiced by Julia Stockton.