The Final Scene is the fifth game in the Nancy Drew adventure series. It is based on Nancy Drew Files #38: The Final Scene.
Nancy's high school friend, Maya Nguyen, is a reporter for Washington University's paper. Nancy joins her at the Royal Palladium Theater in St. Louis to interview movie star Brady Armstrong, whose movie will be the final premiere at the theater before its demolition. However, a few seconds after entering Brady's dressing room, Maya screams for help, calling out Nancy's name. But when Nancy bursts in, Maya's vanished without a trace. Soon after, Nancy gets a disguised phone call telling her that "if the theater goes down, the girl goes with it".
Brady is the star of Vanishing Destiny, the final film to premiere in the Royal Palladium. Maya was supposed to interview him before her kidnapping.
Simone is Brady's agent. She's focused on his career and success, and doesn't hesitate to exploit situations for publicity.
Nick is the leader of the activist group HAD IT (Humans Against the Destruction of Illustrious Theaters). Stationed inside the theatre, he's campaigning for its preservation. However, he seems to have a reputation for taking drastic measures to preserve theatres.
Joe is the theatre's caretaker, who works in the projection room and looks after the theatre.
The phone is located in the ticket booth.
Bess and George are cousins and both are good friends of Nancy. They can give her advice on her case.
Ned is Nancy's boyfriend, and also offers her advice and hints.
Eustacia is an elderly woman who is Harry Houdini's cousin by marriage. Nancy can call her to hopefully find a way to prevent the Royal Palladium theater from being knocked down, given that Harry Houdini had half ownership of it.