Trail of the Twister is the twenty second game in the Nancy Drew adventure series. It is based on Nancy Drew Mystery Stories #155: The Mystery in Tornado Alley. It was promoted with a microsite, a video web series of character interviews which can be found on Her Interactive's website, and a blog of the intern Nancy is replacing. The bar at the top of the box is of a different format so that it advertises that it can be played on both Mac and PC.
The meteorology department of Oklahoma's Canute College is competing in a $100,000,000 competition to develop equipment that can hopefully predict when and where tornadoes will strike. But some of their current equipment starts to mysteriously fail, and members of the team become injured. Is it just bad luck, or sabotage? Tech tycoon P. G. Krolmeister (yes, THE Krolmeister) asks Nancy to join Canute's team as an intern to help out and find the source of the trouble!
Scott is the leader of the Canute team. Short-tempered and pessimistic, he is very dedicated to the study of tornadoes. Some people even call him gifted due to his intuitive link with twisters, but lately he seems even more put out than usual.
Debbie is the project manager. She does most of the work, up to and including putting up with Scott's temper.
Frosty is the team's photographer. His interest in tornadoes started when he was literally caught in one and got some of the best footage to date, as well as his current nickname. He's a bit overconfident about his photography abilities.
Chase is the team's handyman. He is a junior who signed up as a science requirement, but found himself very intrigued by the class.
Pa runs Ma and Pa's General Store. He's a well-loved famous local, and is very serious about tornado safety. He also runs a small museum on Oklahoma history, including the Dust Bowl. He's actually quite a fan of plays and even acts onstage from time to time.
Nancy uses a cell phone that is accessible by an icon at the bottom of the screen.
Frank and Joe are detective brothers and friends of Nancy who can give her advice if she's a Junior Detective. At the moment, they're trying to solve their own case, called Treasure on the Tracks, or as Joe calls it, The Mystery of the Train Trip.
Krolmeister is the one who hired Nancy to find out who was behind the sabotage. He's a bit excitable and has been very interested in tornadoes ever since one tore through his house.
The Trail of the Twister microsite lets people 'join the team' and receive a Canute ID card by completing a quiz. The site also talks about each team member, tornadoes and terminology, and equipment.